![particle playground reverse particle playground reverse](https://i.ytimg.com/vi/Ee0BCoJ1LCE/maxresdefault.jpg)
Furthermore, SPIONs can be used for drug delivery 7.
![particle playground reverse particle playground reverse](https://i.ytimg.com/vi/vAlUNou7DTc/maxresdefault.jpg)
Therefore, the hysteresis of the particles plays a critical role for most applications. In MFH the nanoparticles serve as a medium for deposition of energy to a specific area using hysteresis losses 6. Moreover, magnetic nanoparticles have also been used in magnetic fluid hyperthermia (MFH) 5. The nanoparticles used for the first experiments in MPI were predominately developed for magnetic resonance imaging (MRI) and are of limited use in the excitation fields of an MPI scanner. The quality of MPI images, for example, strongly depends on the anisotropy and size distribution of the SPIONs used as tracer material 3. The properties of the magnetic particles strongly influence their usage for MPI or other applications. The hardware realization for MPI is possible in a number of ways and is illustrated by Buzug et al. It is a quantitative imaging technique, which provides high sensitivity and can provide submillimeter spatial resolution 3. MPI is a tomographic imaging modality measuring the spatial distribution of the SPIONs 1, 2. Magnetic Particle Spectroscopy (MPS) is a technique to characterize superparamagnetic iron oxide nanoparticles (SPIONs) for their possible performance in magnetic particle imaging (MPI). Hence, it is a powerful tool for an in-depth understanding of the nanoparticle formation dynamics during the synthesis process. The device is able to record the changes in the amplitude and phase spectra, and, in turn, the hysteresis. For an alkaline-based precipitation, the change of magnetic properties of SPIONs during the nucleation and growth phase of the synthesis is demonstrated. It has a chamber size of 72 mm such that a 100 ml reaction flask can be used for synthesis. The device is suitable for the use in a biochemistry environment. In this contribution, a novel in-situ magnetic particle spectrometer (INSPECT) is presented, which can be used to monitor the entire synthesis process from particle genesis via growth to the stable colloidal suspension of the nanoparticles in real time. State of the art MPS devices are solely capable of measuring the magnetization response of the SPIONs to an oscillatory magnetic excitation retrospectively, i.e. Magnetic Particle Spectroscopy (MPS) is a measurement technique to determine the magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) in an oscillating magnetic field as applied in Magnetic Particle Imaging (MPI).